The Central Karoo region is a municipal area in the centre of the Karoo with its base in Beaufort West. A pristine landscape, the Karoo is epitomised by expansive arid plains and flat-topped mountain ranges. This dry, barren region is sprinkled with historic towns, hardy wildlife, fossils, rock art and a wine route. It is quiet, has its own distinct smell (from the Karoo bushes) and will definitely find a soft spot in your memories.

Towns in this area include:
- Beaufort West
- Prince Albert
- Laingsburg
- Matjiesfontien